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Mechanochemical Crosstalk Produces Cell-Intrinsic Patterning ...
Dimitracopoulos et al., Curr Biol, 2020.
Here we built a multimodal mechanochemical model to recapitulate a complex experimental workflow, leading to the discovery of an intimate relationship between biochemical signalling and the mechanics of cell division in cancer
FeII4L4 Tetrahedron Binds to Nonpaired DNA Bases
Zhu et al., JACS, July 2019.
A core hypothesis behind our approach is to think about oligonucleotide therapeutics in terms of thermodynamics. In this paper we designed and characterised oligonucleotides and leveraged this knowledge to build machine learning algorithms.
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